A0A0N7AHR9 · A0A0N7AHR9_LUCIL
- ProteinCytochrome b
- Genecob
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids378 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 84 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 98 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 183 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 197 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 202 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Oestroidea > Calliphoridae > Luciliinae > Lucilia
Accessions
- Primary accessionA0A0N7AHR9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-57 | Helical | ||||
Sequence: LLFLCLMIQILTGLFLAMHYT | ||||||
Transmembrane | 78-99 | Helical | ||||
Sequence: WLLRTMHANGASFFFICIYLHV | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: WLVGVIILFLVMGTAFMGYVL | ||||||
Transmembrane | 141-159 | Helical | ||||
Sequence: FWGATVITNLLSAIPYLGI | ||||||
Transmembrane | 179-201 | Helical | ||||
Sequence: FFTFHFILPFIVLAATLIHILFL | ||||||
Transmembrane | 230-251 | Helical | ||||
Sequence: IVGFVVMTMILLLLVLINPYLL | ||||||
Transmembrane | 289-309 | Helical | ||||
Sequence: LGGVIALVLSIAILAILPFYH | ||||||
Transmembrane | 321-341 | Helical | ||||
Sequence: INQILFWVMVVTVILLTWIGA | ||||||
Transmembrane | 348-370 | Helical | ||||
Sequence: YVLVGQILTVVYFAYFMFNPLII |
Keywords
- Cellular component
Interaction
Subunit
The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-210 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MNKPLRIKHPIFSIANSALVDLPAPINISAWWNFGSLLFLCLMIQILTGLFLAMHYTADINLAFNSVNHICRDVNYGWLLRTMHANGASFFFICIYLHVGRGIYYGSYLFTPTWLVGVIILFLVMGTAFMGYVLPWGQMSFWGATVITNLLSAIPYLGIDLVQWVWGGFAVDNATLTRFFTFHFILPFIVLAATLIHILFLHETGSSNPM | ||||||
Domain | 211-378 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GLNSNIDKIPFHPYFTFKDIVGFVVMTMILLLLVLINPYLLGDPDNFIPANPLVTPVHIQPEWYFLFAYAILRSIPNKLGGVIALVLSIAILAILPFYHLSKFRGIQFYPINQILFWVMVVTVILLTWIGARPVEEPYVLVGQILTVVYFAYFMFNPLIIKWWDNLLN |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length378
- Mass (Da)43,056
- Last updated2016-01-20 v1
- Checksum843D2830D3C8D865
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KM657109 EMBL· GenBank· DDBJ | AJO61925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM657110 EMBL· GenBank· DDBJ | AJO61938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT272845 EMBL· GenBank· DDBJ | AMH85446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT584139 EMBL· GenBank· DDBJ | QLY90030.1 EMBL· GenBank· DDBJ | Genomic DNA |