A0A0N5D560 · A0A0N5D560_THECL
- ProteinVacuolar protein sorting-associated protein 16 homolog
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids881 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | CORVET complex | |
Cellular Component | HOPS complex | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Molecular Function | actin binding | |
Biological Process | endosomal transport | |
Biological Process | intracellular protein transport | |
Biological Process | vacuole fusion, non-autophagic |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameVacuolar protein sorting-associated protein 16 homolog
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Thelazioidea > Thelaziidae > Thelazia
Accessions
- Primary accessionA0A0N5D560
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Late endosome membrane ; Peripheral membrane protein
Lysosome membrane ; Peripheral membrane protein
Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 31-399 | Vps16 N-terminal | ||||
Sequence: DNCLFASSPYGGCIAYAFPNTSFWIITIKTNAGKLLSTFKAHNVHSIYWTRCHRLVIVNVRGRVHVYTPLGKLKYQFVMDEEITVVETRIYYGGVGNTGIAVLSENNRIYAVNSVMEAVPWRVPDIAKSNLLSTWNVLTFVNVTILSVIGTAFYASMQGLAPQLLELPWKIDSGEYINIIPNWDSTRIALLHSSFIVQIIDSDFSLLFTLSLSAVDNVRAISNIVWCGNEVLSMKHSRHSVFLISVCSKSHVYDFETCVEIDMELDGIKVFTSNQLILLSQVPDAVDCVLSVASVQPGAILYDASEKLVEGTYGVYEYIQMIESQMEDAIQQCLLAAAHQFDSVLQKKMLRAASLGKSLVKRQDASQFV | ||||||
Domain | 505-716 | Vps16 C-terminal | ||||
Sequence: VSFADVAMKAADANLNELAELLLDRETCLSRQVEVLMKLNKVDRALAKAAKSQQPDLLHYVLTYLKRTEKKEIIDHLVLKLPQALCLYQDYLKDEAPRHLLALYVQKDDFARQSLYYLKESELTPWNPFDNKDKIEELLKAETSLNKLKEHTTAQLVAETGELFRICEALDGKPDFIDVDRTSVRSVYIWAVGHHEDILVEQLKKKFKLTEK |
Sequence similarities
Belongs to the VPS16 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length881
- Mass (Da)100,551
- Last updated2015-12-09 v1
- ChecksumC15EA6FC13369C07
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
UYYF01004586 EMBL· GenBank· DDBJ | VDN05647.1 EMBL· GenBank· DDBJ | Genomic DNA |