A0A0N0TTV2 · A0A0N0TTV2_9ACTN

Function

function

Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.
siroheme (UniProtKB | Rhea| CHEBI:60052 )

Note: Binds 1 siroheme per subunit.

Pathway

Nitrogen metabolism; nitrate reduction (assimilation).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site642[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site648[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site682[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site686[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site686Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionsulfite reductase (ferredoxin) activity
Biological Processnitrate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    assimilatory sulfite reductase (ferredoxin)
  • EC number

Gene names

    • ORF names
      ADL06_11810

Organism names

  • Taxonomic identifier
  • Strain
    • NRRL F-6491
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0N0TTV2

Proteomes

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-302FAD/NAD(P)-binding
Domain332-390NADH-rubredoxin oxidoreductase C-terminal
Domain431-473BFD-like [2Fe-2S]-binding
Domain561-622Nitrite/Sulfite reductase ferredoxin-like
Domain633-769Nitrite/sulphite reductase 4Fe-4S

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    846
  • Mass (Da)
    89,721
  • Last updated
    2015-12-09 v1
  • Checksum
    3FD3DCC46D96D2C0
MSADADTAAHTPTIVLVGHGMVGQRFLEALADRGVTGRARIVVLCEEPRPAYDRVQLTSYFSGKTPDDLSVVGAGFMAEHGIELYVGDAAASVDREARTVTARSGRVFAYDTLVLATGSYPFVPPVPGKDARGCFVYRTIEDLLAIEEYAKTATTGAVVGGGLLGLEAAGALKGLGLETHVVEFAPRLMPVQVDEGGGAALLRTIERMGLGVHTGTGTQEVVTADGAVTGMRLSDGSELAVDMVVFSAGVRPRDQLARDCGLAVGERGGIAVDELCRTSDPAVFAIGECALAVDGRVYGLVAPGYEMAQTVAAVLSEGAEEAGDGFTGADMSTKLKLLGVDVASFGDAHGTAEGCLDVVYADSRSGVYKKLVVDREGVLLGGVLVGDADSYGLLRPLTGTVPPVSPEQLVLPAGAGAPVALGPSSLPDDAVICSCHNVTKHAIGQCSSLAEVKKCTKAGTGCGSCVKVIEKLLPAPTDRGLCRCFSYGRSELYEIARTLRVTSFAALLDSHGRPEARGGEGCEVCKPTVGSILASLNNGYILDGEQASLQDTNDHFLANMQRNGSYSVVPRIPGGEITPDKLIVIGEVARDYGLYTKITGGQRIDLFGARVDQLPAIWTRLVDAGFESGHAYGKSLRTVKSCVGQTWCRYGVQDSVKMAIHLELRYRGLRAPHKLKSAVSGCARECAEAQSKDFGIIATANGWNLYVGGNGGATPRHADLLAQDLSDAELIRLIDRFLMFYIRTADRLERTSTWLERLEGGLEHLKDVVVHDSLGLCDELEALMAAHVDAYRDEWAQTLDDPERLRRFVSFVNAPDAPDPSVRFVPERDQIKPDLTFLTLEGVASR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGEE01000115
EMBL· GenBank· DDBJ
KOX30841.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp