A0A0M9EQT6 · DEP3_FUSLA
- ProteinEfflux pump DEP3
- GeneDEP3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids550 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Efflux pump; part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).
Is presumed either to be responsible for exporting depudecin, to provide self-protection, or both (PubMed:19737099).
Is presumed either to be responsible for exporting depudecin, to provide self-protection, or both (PubMed:19737099).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEfflux pump DEP3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium
Accessions
- Primary accessionA0A0M9EQT6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 44-64 | Helical | ||||
Sequence: AIAYAAMLSTTFLFALDNTIV | ||||||
Transmembrane | 78-98 | Helical | ||||
Sequence: LELISWIGTGFALGTMFILLW | ||||||
Transmembrane | 109-129 | Helical | ||||
Sequence: WVYIFNILLFEVGSAVCGAAP | ||||||
Transmembrane | 139-159 | Helical | ||||
Sequence: VIAGIGGSGMYSGTLTYVSVL | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: STVVWGVGSVVGPVVGGAFAA | ||||||
Transmembrane | 199-219 | Helical | ||||
Sequence: WGFYINLPIGAVFAPAYMILF | ||||||
Transmembrane | 242-262 | Helical | ||||
Sequence: AVIFLAGSACLTVALTFGGVV | ||||||
Transmembrane | 268-288 | Helical | ||||
Sequence: GTIIALWTVTGVLLVAFIVLL | ||||||
Transmembrane | 319-339 | Helical | ||||
Sequence: FLASGIILAMTYYVPLYFQFI | ||||||
Transmembrane | 351-371 | Helical | ||||
Sequence: LLPLIMFMVAFSMVNGFLMPK | ||||||
Transmembrane | 373-393 | Helical | ||||
Sequence: GLIPIWYIVGSALTLIGSALM | ||||||
Transmembrane | 410-430 | Helical | ||||
Sequence: ILVGAGAGCYIVAGFAIVQSL | ||||||
Transmembrane | 439-459 | Helical | ||||
Sequence: AVGAMTISQDLGMVLFLAICG | ||||||
Transmembrane | 515-535 | Helical | ||||
Sequence: SIWAFFMAAAALSFVCSWPLF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000441940 | 1-550 | Efflux pump DEP3 | |||
Sequence: MSEQSTLAGPYTEKPGVESQNPTGDGKASFDETSPRDIHGWRWAIAYAAMLSTTFLFALDNTIVANIQPSIINDFGHLELISWIGTGFALGTMFILLWGKIYGVFNIKWVYIFNILLFEVGSAVCGAAPNIQALIIGRVIAGIGGSGMYSGTLTYVSVLSNQKEKPAYLAGSTVVWGVGSVVGPVVGGAFAASSATWRWGFYINLPIGAVFAPAYMILFPNWDPNPTLTLAEKFRLVDWINAVIFLAGSACLTVALTFGGVVYSFNSGTIIALWTVTGVLLVAFIVLLKLHPLVSKENRLYPLHFFKQMTLINMQLQVFLASGIILAMTYYVPLYFQFIKGDGALQAGVRLLPLIMFMVAFSMVNGFLMPKYGLIPIWYIVGSALTLIGSALMYTIDENTSNGNVYGYNILVGAGAGCYIVAGFAIVQSLVPTHEIANAVGAMTISQDLGMVLFLAICGSLFHNVAVDKVGKALPSASETEIGNLIAGTSSSAFQALSEADKDLVIPEIASAMKSIWAFFMAAAALSFVCSWPLFKTKLGGKKVEASVVV | ||||||
Glycosylation | 399 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Induction
Expression correlates with the production of depudecin with high levels on oat grain medium, and minimal levels on oat flower medium and complete medium (PubMed:28460114).
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-33 | Disordered | ||||
Sequence: MSEQSTLAGPYTEKPGVESQNPTGDGKASFDET |
Sequence similarities
Belongs to the major facilitator superfamily. TCR/Tet family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length550
- Mass (Da)58,918
- Last updated2015-12-09 v1
- Checksum26E05815594AB658
Keywords
- Technical term