A0A0M9EQT6 · DEP3_FUSLA

  • Protein
    Efflux pump DEP3
  • Gene
    DEP3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Efflux pump; part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).
Is presumed either to be responsible for exporting depudecin, to provide self-protection, or both (PubMed:19737099).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Efflux pump DEP3
  • Alternative names
    • Depudecin biosynthesis cluster protein 3

Gene names

    • Name
      DEP3
    • ORF names
      FLAG1_09234

Organism names

  • Taxonomic identifier
  • Strain
    • Fl201059
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium

Accessions

  • Primary accession
    A0A0M9EQT6

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane44-64Helical
Transmembrane78-98Helical
Transmembrane109-129Helical
Transmembrane139-159Helical
Transmembrane172-192Helical
Transmembrane199-219Helical
Transmembrane242-262Helical
Transmembrane268-288Helical
Transmembrane319-339Helical
Transmembrane351-371Helical
Transmembrane373-393Helical
Transmembrane410-430Helical
Transmembrane439-459Helical
Transmembrane515-535Helical

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004419401-550Efflux pump DEP3
Glycosylation399N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression correlates with the production of depudecin with high levels on oat grain medium, and minimal levels on oat flower medium and complete medium (PubMed:28460114).

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-33Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    58,918
  • Last updated
    2015-12-09 v1
  • Checksum
    26E05815594AB658
MSEQSTLAGPYTEKPGVESQNPTGDGKASFDETSPRDIHGWRWAIAYAAMLSTTFLFALDNTIVANIQPSIINDFGHLELISWIGTGFALGTMFILLWGKIYGVFNIKWVYIFNILLFEVGSAVCGAAPNIQALIIGRVIAGIGGSGMYSGTLTYVSVLSNQKEKPAYLAGSTVVWGVGSVVGPVVGGAFAASSATWRWGFYINLPIGAVFAPAYMILFPNWDPNPTLTLAEKFRLVDWINAVIFLAGSACLTVALTFGGVVYSFNSGTIIALWTVTGVLLVAFIVLLKLHPLVSKENRLYPLHFFKQMTLINMQLQVFLASGIILAMTYYVPLYFQFIKGDGALQAGVRLLPLIMFMVAFSMVNGFLMPKYGLIPIWYIVGSALTLIGSALMYTIDENTSNGNVYGYNILVGAGAGCYIVAGFAIVQSLVPTHEIANAVGAMTISQDLGMVLFLAICGSLFHNVAVDKVGKALPSASETEIGNLIAGTSSSAFQALSEADKDLVIPEIASAMKSIWAFFMAAAALSFVCSWPLFKTKLGGKKVEASVVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JXCE01000338
EMBL· GenBank· DDBJ
KPA37943.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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