A0A0M0BNL0 · A0A0M0BNL0_9ARCH

Function

function

Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N6-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
Molecular FunctionN6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Biological Process'de novo' AMP biosynthetic process
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate lyase
  • EC number
  • Short names
    ASL
  • Alternative names
    • Adenylosuccinase

Gene names

    • ORF names
      AC480_01740

Organism names

Accessions

  • Primary accession
    A0A0M0BNL0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain362-442Adenylosuccinate lyase C-terminal

Sequence similarities

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    49,821
  • Last updated
    2015-11-11 v1
  • Checksum
    619E1FB14A432BB9
MPILPIDMGRYGSRAMKAIFDEEGKLQRLLDVEAALAWAHAEVGDIPKADGERIGAMASVKHVRLTRVKEIEAEINHDVMAVVQALSEACGASGAYVHLGATSNDITDSATALQLKDAIGLIKERLDVLEGVLITLAKENKGTLIIGRTHGQHAVPTTLGFKFVVWLREVARHLTRLEECSDRVIVGKMSGAVGTQAGFGPKALQIQHLTMARLGIQAADVSTQIVPRDVYAELICLFANLASSLDKFALEIRQLQRPEIAELAEPFERGKQVGSSTMPHKRNPILCERVCGLAKILRSLTLPALENVPTWHERDITQSSAERFILPEACILLDYMLSLMTRVLQHLHIDRERMRTNLDITQGRAMSESVMLTLTRKGLGRQRAHSLVREIALTSEQEGTSFRDALLATPDIRKVLSENEVDAALDPANYLGTALEQIDAMITKTEAERRQT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LFWX01000020
EMBL· GenBank· DDBJ
KON30172.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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