A0A0K1ZZI8 · A0A0K1ZZI8_9CARN

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Vulpes

Accessions

  • Primary accession
    A0A0K1ZZI8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane5-22Helical
Transmembrane57-80Helical
Transmembrane92-115Helical
Transmembrane153-171Helical
Transmembrane208-230Helical
Transmembrane237-261Helical
Transmembrane281-305Helical
Transmembrane325-346Helical

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-287NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain290-343NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,796
  • Last updated
    2015-11-11 v1
  • Checksum
    B72DD3AA5E7F1CC4
MKPPILIIILATVMTGTMIVMLSSHWLLIWIGFEMNMLAIIPILMKKFNPRAMEASTKYFLTQATASMLLMMGVTINLLYSGQWMVSKVSNPAASIMMTIALTMKLGLSPFHFWVPEVTQGVSLSSGMILLTWQKIAPMSILYQISPSINTDLMMLMALASVLTGGWGGLNQTQLRKIMAYSSIAHMGWMTAIIIYNPTMMFLNLSLYILMTLSTFMLFMLSASTTTLSLSHTWNKIPLIASTILTLMLSLGGLPPLSGFIPKWMIIQELTKNGMIVTPTLMAITALLNLYFYMRLTYSTALTMFPSANNMKMKWQFEHTKKTTLLPPLIIISTMLLPITPMMSILD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT033906
EMBL· GenBank· DDBJ
AKZ31808.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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