A0A0J9UBD6 · LAEA_FUSO4
- ProteinSecondary metabolism regulator laeA
- GenelaeA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids316 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Methyltransferase that performs automethylation (By similarity).
No other methyl-accepting substrate has been identified yet (By similarity).
Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23106229).
Controls the biosynthetic gene cluster for beauvericin, a depsipeptide mycotoxin that functions as a virulence determinant (PubMed:23106229).
The velvet complex regulates also chromatin structure and transcription of siderophore biosynthetic genes and is required for infection of tomato plants (PubMed:23106229).
The velvet complex also governs expression of nitrate metabolism genes (PubMed:24240057).
No other methyl-accepting substrate has been identified yet (By similarity).
Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23106229).
Controls the biosynthetic gene cluster for beauvericin, a depsipeptide mycotoxin that functions as a virulence determinant (PubMed:23106229).
The velvet complex regulates also chromatin structure and transcription of siderophore biosynthetic genes and is required for infection of tomato plants (PubMed:23106229).
The velvet complex also governs expression of nitrate metabolism genes (PubMed:24240057).
Catalytic activity
- L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | methyltransferase activity | |
Biological Process | methylation | |
Biological Process | sporulation resulting in formation of a cellular spore |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSecondary metabolism regulator laeA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium oxysporum species complex
Accessions
- Primary accessionA0A0J9UBD6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000435752 | 1-316 | Secondary metabolism regulator laeA | |||
Sequence: MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRPSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLTDCDLIHMRMLLGSIQTDLWPQVYHNVFEHLTPGIGFFEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVTPQEHRQMLEAAGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ |
Structure
Family & Domains
Sequence similarities
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length316
- Mass (Da)36,726
- Last updated2015-10-14 v1
- ChecksumB31FF99C55701147
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS231696 EMBL· GenBank· DDBJ | KNA95390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DS231696 EMBL· GenBank· DDBJ | KNA95386.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
DS231696 EMBL· GenBank· DDBJ | KNA95387.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
DS231696 EMBL· GenBank· DDBJ | KNA95389.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
DS231696 EMBL· GenBank· DDBJ | KNA95388.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |