A0A0J9UBD6 · LAEA_FUSO4

Function

function

Methyltransferase that performs automethylation (By similarity).
No other methyl-accepting substrate has been identified yet (By similarity).
Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23106229).
Controls the biosynthetic gene cluster for beauvericin, a depsipeptide mycotoxin that functions as a virulence determinant (PubMed:23106229).
The velvet complex regulates also chromatin structure and transcription of siderophore biosynthetic genes and is required for infection of tomato plants (PubMed:23106229).
The velvet complex also governs expression of nitrate metabolism genes (PubMed:24240057).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Secondary metabolism regulator laeA
  • Alternative names
    • Methyltransferase laeA
      (EC:2.1.1.-
      ) . EC:2.1.1.- (UniProtKB | ENZYME | Rhea)
    • Velvet complex subunit laeA

Gene names

    • Name
      laeA
    • ORF names
      FOXG_00975

Organism names

Accessions

  • Primary accession
    A0A0J9UBD6
  • Secondary accessions
    • A0A0D2XAQ9
    • A0A0J9U886
    • A0A0J9U8U0
    • A0A0J9WGP4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Impairs production of beauvericin and attenuates virulence during infection of tomato plants (PubMed:23106229).
Impairs also growth on the non-preferred nitrogen sources nitrate and nitrite (PubMed:24240057).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004357521-316Secondary metabolism regulator laeA

Interaction

Subunit

Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (PubMed:23106229).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    36,726
  • Last updated
    2015-10-14 v1
  • Checksum
    B31FF99C55701147
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRPSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLTDCDLIHMRMLLGSIQTDLWPQVYHNVFEHLTPGIGFFEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVTPQEHRQMLEAAGFTDIRQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEEVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ

Sequence caution

The sequence KNA95386.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence KNA95387.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence KNA95388.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence KNA95389.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231696
EMBL· GenBank· DDBJ
KNA95390.1
EMBL· GenBank· DDBJ
Genomic DNA
DS231696
EMBL· GenBank· DDBJ
KNA95386.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
DS231696
EMBL· GenBank· DDBJ
KNA95387.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
DS231696
EMBL· GenBank· DDBJ
KNA95389.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
DS231696
EMBL· GenBank· DDBJ
KNA95388.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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