A0A0H5C7U4 · A0A0H5C7U4_CYBJN
- ProteinChitobiosyldiphosphodolichol beta-mannosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids445 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc2-Man5 intermediate on the cytoplasmic surface of the ER.
Catalytic activity
- an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19510 + CHEBI:57527 = a β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19511 + CHEBI:58189 + CHEBI:15378
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | chitobiosyldiphosphodolichol beta-mannosyltransferase activity | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChitobiosyldiphosphodolichol beta-mannosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Phaffomycetaceae > Cyberlindnera
Accessions
- Primary accessionA0A0H5C7U4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 17-39 | Helical | ||||
Sequence: WVYWLIGIYLLLPTIYLIVPFIY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 257-421 | Glycosyl transferase family 1 | ||||
Sequence: FKNFSPSSDKIIVSSTSFTPDEDFNVLVEALVKYDTLHDDNLPKLKVIITGKGPLKEQFLKAIEAANLQKSDVQCAWLAAEEYPKILAIADIGISLHTSSSGIDLPMKVVDMFGCGVPVLALEFDALPELVDDGINGMRVLDARQIVESFIYLFLQPSNYKVIKK |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length445
- Mass (Da)50,224
- Last updated2015-10-14 v1
- Checksum83CF8780C478C0C9