A0A0F4ZCP6 · A0A0F4ZCP6_9PEZI

  • Protein
    Mediator of RNA polymerase II transcription subunit 5
  • Gene
    MED5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmediator complex
Molecular Functiontranscription coregulator activity
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mediator of RNA polymerase II transcription subunit 5
  • Alternative names
    • Mediator complex subunit 5

Gene names

    • Name
      MED5
    • ORF names
      TD95_000200

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CR-DP1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Microascales > Ceratocystidaceae > Thielaviopsis

Accessions

  • Primary accession
    A0A0F4ZCP6

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the Mediator complex.

Family & Domains

Sequence similarities

Belongs to the Mediator complex subunit 5 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,063
  • Mass (Da)
    117,263
  • Last updated
    2015-06-24 v1
  • Checksum
    2F3A296B38880D55
MAAAAHQPDAVPLGDASSQLNNNPPALKCRMTRLKEVVLPLRKYAYIRWKNFMTHMVHNRACEETFHRSASNMWKKHYIPPDALAKLMLAPRFDGYMLDPRTHLYINKCLTLGYLDIPSVLAGQLKYTSLGNFATPDIDPTKEPVTRWKGSFSSDEVLFWRLAKCIGQAGTSPETPRISADVALHTVLRMATWVELFNKVFETLSKDTMRQKYDNNLRAEIESTHAAFVGLLLKVCESRAVLNALDKKVAGRCRRAIVKNLPRFISSIQVQPIAERLNMFRQKMAKYDVKKPVDGEEADDGIDSAASVMALESTSGKRIPPTNSRAGLYIYLNACLVGRPVIDDAILCNWIRNRYNPEIHVGIVDLILASFDVLSNAAFRNEHRSTAQLLRSYLTNKLPLLILNLALGLYPPTLSEFCITTALGQVDPSVFPTLTGMFDDTRNNNDFTENMREEFCFACCLHGLISQANISALLGDTYSSLPAEGKRVKAALVQECAGNSDYIVSLLASLDKTDGNVGAVCEALVEVFGELCANRDTATLKTLCSQLALQPMSLDVIQLFEKPVKLLQPLCHLLDEWRYDDEQTEYQSVYEEFGSVLLLVMVFAYRYNLSPPDMGIRSPDSFVARLIREGHLSKALYELSPAEDACLTGWIHGLFGTDTGGLSDELLASCPPQDFYLLVSTLFKNIVVANSEGCLSMEALKNGIEYLVDTFLMPSLVPAVLFLADQLSVDQEPEQQAMVNVLHMILKPKAIHTNTGKMLAAVKNLTAKPLERALRRYQRRYPTSEQVEPLLVVIKDNIPLSRRTGGADHNELESWCATPGGGLAIAVRSTIQNFVHWSTDPLAVTPTPYTHRQILVAIRRMTAQHVIRLIIDEIKVHMSHGAPALSLMYDVAIALIVSPEVTNYPEPVAQLVDDSGAMPIPTQRRLTLREVLGMKAATYKTIFRTDPVKAEIVLRLHREVEAQMAPAPVPTLMDADKALPLDTGAERAVAGADAVENLVAQAAPVEGLPETLDLMDMSMGDMGMVNGLGGSGSNLDLGTDADLFGGLGGGDDFGWDNIDVMGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LAEV01001332
EMBL· GenBank· DDBJ
KKA28369.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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