A0A090XCE8 · A0A090XCE8_9PETR

  • Protein
    Tyrosine-protein kinase receptor
  • Gene
    IGF1R
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

111951002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site729ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentinsulin receptor complex
Molecular FunctionATP binding
Molecular Functioninsulin receptor activity
Molecular Functioninsulin receptor substrate binding
Biological Processglucose homeostasis
Biological Processpositive regulation of kinase activity
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor
  • EC number

Gene names

    • Name
      IGF1R

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Cyclostomata > Hyperoartia > Petromyzontiformes > Petromyzontidae > Ichthyomyzon

Accessions

  • Primary accession
    A0A090XCE8

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane630-654Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain311-416Fibronectin type-III
Region371-390Disordered
Region439-460Disordered
Compositional bias446-460Polar residues
Domain530-624Fibronectin type-III
Domain695-970Protein kinase
Compositional bias977-992Basic and acidic residues
Region977-1080Disordered
Compositional bias1016-1038Polar residues
Compositional bias1054-1077Polar residues
Region1095-1195Disordered
Compositional bias1132-1172Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,195
  • Mass (Da)
    134,137
  • Last updated
    2014-11-26 v1
  • Checksum
    54AD57BF4576EDF8
PDCPSGYIRNVTSMTCTKCDGPCPKVCKYGNVNINSLTAAQELYGCTELDGNLTIDIRGGNNIAAELETNLGLIEMVTGYVKIKRSSALVTLAFLKNLRIIRGDMLDEGNYSFYVLDNQNLQQLWDWTKHNLTVLRGKLYFAFNHKLCMSEIYRMESVTGTNGRQSRTDLNPKENGDRTSCESKFLRFTGNETSSDKIKLEWDHTWPKYDRDLLSYTVYYKEAPFKNVSEFDQQDACGSNSWTARDLEFRAGVNPQEMSNPSIILLSLKPWTQYAIFVRAFTLTTTSGDINNQGAKSEVVYIRTKANASSIPLDVIAGSNSSTQLVVKWRAPAYPNGNVTHYIVRWQRQHEDPELRKHDYCNKVLKVPRREPATSSIDMEPGARGNQSELDTSLAPEKCCACPKTQAQLRQEAEEAQFMKTFENFLHNQIFATRPDRKRRDMFGTDNTTDSGNSTSSLIGSEEVTPTPVVYTFAEEMVFGKERITITGLRHFTAYRIQIQACNHASELVGCSAPAYVSARTQPHFDADNITGHVKCEVVKNIIYLQWKEPSDPNGLVVLYEVKYQRDSESQIQQHCVSRSSYREWKGFQVRHLLPGDYTAHIRAISLSGNGSWTEPFHFRIPDPAKKDPLMLAVPVTIAVVFIILGVAMIGFFFMKKRNEAAVPNGVLYASVNPEYFSTADVYIADEWEVERDKVKMMRELGQGTFGMVYEGLARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPARLQELIRKCWQYNPRMRPTFLEILDGLAPDLHPSFHEFSFYHSEENRPPDHDRDPPGMEMQSMQSMQSYPLDEEPCQLEEASPSKSLSPSEVSRASGRFHSSSSPYLAVDMRGTPEKGGRQQLQKQQQQKQQQQQQQVPQSFEKKGPIVDVEVAFAGMPDMREPSSPVPVLGVQAVDERNQPYARLDTLPAEKPPCAESSSESSVPSSPTGSGSVSLSPTKAGVNLPSPTASGNKQLPYAHMNGGRKDGRALPLPQSTAC

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias446-460Polar residues
Compositional bias977-992Basic and acidic residues
Compositional bias1016-1038Polar residues
Compositional bias1054-1077Polar residues
Compositional bias1132-1172Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GBEL01000003
EMBL· GenBank· DDBJ
JAC94717.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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