A0A075WP33 · A0A075WP33_ARCFL
- ProteinPhosphomevalonate dehydratase large subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids372 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of a hydro-lyase that catalyzes the dehydration of mevalonate 5-phosphate (MVA5P) to form trans-anhydromevalonate 5-phosphate (tAHMP). Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Catalytic activity
- (R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2-enoate + H2OThis reaction proceeds in the forward direction.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway.
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomevalonate dehydratase large subunit
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Archaeoglobi > Archaeoglobales > Archaeoglobaceae > Archaeoglobus
Accessions
- Primary accessionA0A075WP33
Proteomes
Interaction
Subunit
Heterodimer composed of a large subunit (PMDh-L) and a small subunit (PMDh-S).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-368 | Phosphomevalonate dehydratase large subunit-like | ||||
Sequence: MYLTKDEERLLESDNDTIRKCMEILVAEGEANEAERLVEVKSAHISGVSYDNIGEAGLEWLESLDAKLKVPATLNPAGMDVERWREMGIDEEFHEKQMRVLRVFERLGVRMTLTCTPYYLLRPEFGDHLAWAESSAIVYANSIIGARTERESGPSAIAAAIIGKIPYYGVHIKENRAPTIFVRLKGDLAAAGYKAGRELRDQIPYFVFDRSVTEEELKLLGAALAATGNTVMFHAENYTPEWKDFEKPAEKIEVDDRLERACEPDLITIGCPHASVRELETILKLMGGRKAKKEFWVFTARDVARKAEKIVQKLEELGVKVFSDTCMVVSPATSKFRCIMVNSGKALYYLPNKRDVDVAFGDLRKCVE |
Sequence similarities
Belongs to the AcnX type II large subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length372
- Mass (Da)41,850
- Last updated2014-10-29 v1
- ChecksumAF2200680707A32A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP006577 EMBL· GenBank· DDBJ | AIG99343.1 EMBL· GenBank· DDBJ | Genomic DNA |