A0A024SEE3 · A0A024SEE3_HYPJR

Function

function

Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentPrp19 complex
Cellular ComponentU2-type catalytic step 1 spliceosome
Molecular Functionubiquitin protein ligase activity
Biological ProcessDNA repair
Biological ProcessmRNA splicing, via spliceosome
Biological Processprotein K63-linked ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pre-mRNA-processing factor 19
  • EC number

Gene names

    • ORF names
      M419DRAFT_128129

Organism names

Accessions

  • Primary accession
    A0A024SEE3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain, region, repeat.

TypeIDPosition(s)Description
Domain1-69U-box
Region166-191Disordered
Repeat271-312WD

Sequence similarities

Belongs to the WD repeat PRP19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    475
  • Mass (Da)
    50,642
  • Last updated
    2014-07-09 v1
  • Checksum
    BBB4DE7E9948D51E
MLCGISGEAPQEPVASKKSGIVYEKRLIEQYINEHGTEPNGEALTVEDLLPINTSRIPRPRPPTLTSIPALLATFQNEWDNLALETYNLREQLARTREELATALYQHDAAVRVIARLTKERDEARDSLSKITVTDGAANGDGMVVDSVEALPEDLAAQVDSVHQSLSKGRKKRSVPEGWVSSDQVSSFETTTTNALPVPRATALDVEGSYAVAGGLNGEAAIYSVEADNVERTIPVGEPVTDTLWAGSKVFFATSQGNVKVYEAGNEVGTLSEHAGPASGLSLHPSGDLLASVGTDKSIVFYHLETMKRVSRAYADASLTTCAFHPDGHLFAAGTVTGDIKLYMTKNLEQAVVFKLGAPVQALVFSENGFMLAATAKGQTSVTIFDLRKEGDAAVSKVLETGGSVQSLAWDYTGQFLATGGATGITVQQYTKSSKKWSEPLRNSVAAVAVRWGESGQKLISLNGEGVVTVLGVKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI911142
EMBL· GenBank· DDBJ
ETS03709.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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