A0A024GKK8 · A0A024GKK8_9STRA
- ProteinSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 42-45 | CoA (UniProtKB | ChEBI) | ||||
Sequence: TGKQ | ||||||
Binding site | 68 | CoA (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 121-123 | CoA (UniProtKB | ChEBI) | ||||
Sequence: ITE | ||||||
Binding site | 185 | substrate; ligand shared with subunit beta | ||||
Sequence: Y | ||||||
Active site | 275 | Tele-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex (ADP-forming) | |
Molecular Function | nucleotide binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | succinate-CoA ligase (GDP-forming) activity | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Albuginales > Albuginaceae > Albugo
Accessions
- Primary accessionA0A024GKK8
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-125 | CoA-binding | ||||
Sequence: WINKETKVICQGFTGKQGTFHSEQAISYGTKMVGGVTPKKGGSTHLGLPVFNTVSEAKRATNADASVIYVPPPFCAQAIIDAIEAEIPLIVAITEGI |
Sequence similarities
Belongs to the succinate/malate CoA ligase alpha subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)34,260
- Last updated2014-07-09 v1
- ChecksumA6A24E09B9B37082
Keywords
- Technical term