Proteomes · Streptococcus pneumoniae (strain CGSP14)

Description

A Gram-positive nonmotile bacterium, Streptococcus pneumoniae is the most common bacterial cause of acute respiratory infection and otitis media, and is estimated to result in over 1 millions deaths in children, the elderly, debilitated and immunosuppressed people every year. Since 1990 the number of penicillin-resistant strains has increased and many strains are now resistant to commonly prescribed antibiotics such as penicillin, macrolides and fluoroquinones. Strain CGSP14 is serotype 14, which is one of the most common pneumococcal serotypes that causes invasive pneumococcal diseases worldwide. Strain CGSP14 is a clinical strain isolated from a child in Taiwan who had a necrotizing pneumonia with complicating hemolytic uremic syndrome. Serotype 14 strains often express resistance to a variety of antimicrobial agents. Strain CGSP14 contains 80 insertion sequence elements, only 12 of which still appear to be intact. It encodes 18 antimicrobial resistance determinants, nearly half of which were associated with mobile genetic elements and were presumably acquired by horizontal gene transfer. Other genes that may contribute to pathogenicity of strain CGSP14 are also encoded in these mobile elements (such as capsule synthesis). Adapted from PubMed 19361343.

Components

Component nameGenome accession(s)Protein count
ChromosomeCP0010332,193

Publications

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