A0KXS9 · GLO2_SHESA
- ProteinHydroxyacylglutathione hydrolase
- GenegloB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids267 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Catalytic activity
- an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Pathway
Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 57 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 59 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 60 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 121 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 138 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 138 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 176 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydroxyacylglutathione hydrolase activity | |
Molecular Function | metal ion binding | |
Biological Process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxyacylglutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA0KXS9
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000144812 | 1-267 | Hydroxyacylglutathione hydrolase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length267
- Mass (Da)29,391
- Last updated2006-12-12 v1
- MD5 Checksum83A154CFBB5C423D10AAEAA30970FBD8
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000469 EMBL· GenBank· DDBJ | ABK48598.1 EMBL· GenBank· DDBJ | Genomic DNA |